Endocrine dirsuptors are supposed to modulate function of nuclear receptors by binding their ligand-binding domain. As nuclear receptors are ligand dependent transcription factor, endocrine disruptors function as agonist or antagonist. Although actual mechanism of endocrine disruption is not well understood, several nuclear receptors are reported as targets of endocrine disruptors. In this review, the functions of nuclear receptors suspected as targets of endocrine disruptors are described.
|ジャーナル||Nippon rinsho. Japanese journal of clinical medicine|
|出版ステータス||出版済み - 2 2002|
All Science Journal Classification (ASJC) codes