Endogenous IL-15 might be responsible for early protection by natural killer cells against infection with an avirulent strain of Salmonella choleraesuis in mice

Kenji Hirose, Hitoshi Nishimura, Tetsuya Matsuguchi, Yasunobu Yoshikai

    研究成果: Contribution to journalArticle査読

    36 被引用数 (Scopus)

    抄録

    Interleukin (IL)-15 is a novel cytokine with growth factor activity for T cells, B cells, and natural killer cells (NK cells). We investigated the role of IL-15 in the host defense against infection with avirulent Salmonella choleraesuis strain 31N-1 cured of 50-kb virulent plasmid. IL-15 was abundantly expressed at transcription and protein levels in macrophages infected with S. choleraesuis 31N-1. The number of NK cells in the infected sites was increased during the course of infection coincident with IL-15 production. Anti-IL-15 mAb administration inhibited the emergence of NK cells and interferon-γ (IFN-γ) production in serum after infection with S. choleraesuis 31N-1 and concurrently impaired the clearance of the bacteria. These results suggested that IL-15 might be responsible for protection against avirulent S. choleraesuis infection at early stage of infection through activation of NK cells in the infected sites.

    本文言語英語
    ページ(範囲)382-390
    ページ数9
    ジャーナルJournal of Leukocyte Biology
    66
    3
    DOI
    出版ステータス出版済み - 1999

    All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学
    • 細胞生物学

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