Endothelium-dependent forearm vasodilation to acetylcholine but not to substance P is impaired in patients with heart failure

Y. Hirooka, T. Imaizumi, S. Harada, H. Masaki, M. Momohara, T. Tagawa, A. Takeshita

    研究成果: Contribution to journalArticle査読

    52 被引用数 (Scopus)

    抄録

    It has been shown that endothelium-dependent vasorelaxation in response to muscarinic stimulation is attenuated in patients as well as animals with heart failure. This study aimed to determine if endothelium-dependent forearm vasodilation evoked with substance P (SP) as well as acetylcholine (ACh) was impaired in patients with heart failure. Forearm blood flow was measured using a strain-gauge plethysmograph and forearm vascular responses to intra- arterial infusions of ACh, SP, or sodium nitroprusside (SNP) at graded doses were examined. The drugs caused the dose-dependent increases in forearm blood flow (FBF) and the decreases in forearm vascular resistance (FVR) in patients with heart failure as well as normal subjects. However, the percent decreases in FVR by ACh were less in patients with heart failure than in normal subjects (p < 0.01). In contrast, the percent decreases in FVR by SP or SNP did not differ between the two groups. These results suggest that endothelium-dependent vasodilation of forearm resistance vessels via muscarinic receptors is specifically impaired, whereas via SP receptors is preserved in patients with heart failure.

    本文言語英語
    ページ(範囲)S221-S225
    ジャーナルJournal of Cardiovascular Pharmacology
    20
    SUPPL. 12
    DOI
    出版ステータス出版済み - 1 1 1992

    All Science Journal Classification (ASJC) codes

    • 薬理学
    • 循環器および心血管医学

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