Enhanced angiogenesis in bFGF-containing scaffold promoted viability of enclosed hepatocytes and maintained hepatospecific glycogen storage capacity

Takayuki Takei, Hiroyuki Ijima, Shinji Sakai, Tsutomu Ono, Koei Kawakami

研究成果: Contribution to journalArticle査読

6 被引用数 (Scopus)

抄録

We fabricated a scaffold of poly (lactic acid) and acidic gelatin, a sustained-release carrier of basic fibroblast growth factor (bFGF), which is a positive regulator of angiogenesis. After 1 week of implantation into mesentery of rats, blood vessels induced in the bFGF-containing scaffolds were almost double those in the bFGF-free scaffolds. Further, histological examination of hepatocyte-immobilizing scaffolds retrieved after 1 week of implantation into the mesentery of the rats that received a 70% hepatectomy revealed that the bFGF-containing scaffolds were more efficient for immobilized cell survival than the bFGF-free scaffolds. As well, hepatocytes in the bFGF-containing scaffolds kept their hepatospecific glycogen storage capacity.

本文言語英語
ページ(範囲)913-917
ページ数5
ジャーナルJOURNAL OF CHEMICAL ENGINEERING OF JAPAN
38
11
DOI
出版ステータス出版済み - 11 20 2005

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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