Enhanced metastatic growth after local tumor resection in the presence of synchronous metastasis in a mouse allograft model of neuroblastoma

Maho Inoue, Yoshiki Tsuchiya, Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Yuichi Togashi, Junnosuke Maniwa, Mayumi Higashi, Shigehisa Fumino, Tatsuro Tajiri, Kazuhiro Yagita

研究成果: Contribution to journalArticle査読

抄録

Purpose: We investigated how local tumor resection affects metastatic lesions in neuroblastoma. Methods: MYCN Tg tumor-derived cells were injected subcutaneously into 129+Ter/SvJcl wild-type mice. First, the frequency of metastasis-bearing mice was investigated immunohistochemically (metastatic ratio) at endpoint or post-injection day (PID) 90. Second, the threshold volume of local tumor in mice bearing microscopic lymph node metastasis (mLNM) was investigated at PID 30. Finally, local tumors were resected after exceeding the threshold. Mice were divided into local tumor resection (Resection) and observation (Observation) groups, and the metastatic ratio and volume of LNM were compared between the groups at endpoint or PID 74. Results: The metastatic ratio without local resection was 88% at PID 78–90. The threshold local tumor volume in the mice with mLNM was 745 mm3 at PID 30, so local tumors were resected after exceeding 700 mm3. The metastatic ratio and LNM volume were significantly greater in the Resection group (n = 16) than in the Observation group (n = 16) (94% vs. 38%, p < 0.001; 2092 ± 2310 vs. 275 ± 218 mm3, p < 0.01; respectively) at PID 50–74. Conclusion: Local tumor resection might augment the growth of synchronous microscopic metastases. Our results provide insights into the appropriate timing of local resection for high-risk neuroblastoma.

本文言語英語
ページ(範囲)1403-1411
ページ数9
ジャーナルPediatric surgery international
35
12
DOI
出版ステータス出版済み - 12 1 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 外科

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