Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi, Keizo Ohnaka, Ryoichi Takayanagi, Fumio Umeda, Hajime Nawata

研究成果: Contribution to journalArticle査読

173 被引用数 (Scopus)

抄録

We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

本文言語英語
ページ(範囲)16-18
ページ数3
ジャーナルFEBS Letters
267
1
DOI
出版ステータス出版済み - 7 2 1990

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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