Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cells

Teruaki Yamauchi, Keizo Ohnaka, Ryoichi Takayanagi, Fumio Umeda, Hajime Nawata

研究成果: ジャーナルへの寄稿記事

167 引用 (Scopus)

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We have investigated the effect of glucose on the release of endothelin-1-like immunoreactivity (ET-l-LI) from cultured bovine aortic endothelial cells. Elevation of glucose concentrations in cultured media from 5.5 to 11.1 or 22.2 mM significantly stimulated ET-1-LI release from cultured endothelial cells. An aldose reductase inhibitor did not affect the high glucose-induced ET-1-LI release, These findings suggest the possibility that hyperglycemia in diabetic patients enhances ET-1-LI release at the local site of vascular endothelium. which might be involved in the developments of vascular complications and atherosclerosis.

元の言語英語
ページ(範囲)16-18
ページ数3
ジャーナルFEBS Letters
267
発行部数1
DOI
出版物ステータス出版済み - 7 2 1990

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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