Enhanced sensitivity of a surface-plasmon-resonance (SPR) sensor for 2,4-D by controlled functionalization of self-assembled monolayer-based immunosensor chip

Sook Jin Kim, K. Vengatajalabathy Gobi, Hiroyuki Tanaka, Yukihiro Shoyama, Norio Miura

研究成果: Contribution to journalArticle査読

20 被引用数 (Scopus)

抄録

A highly sensitive SPR immunosensor has been fabricated by covalent binding of a protein conjugate of 2,4-D (2,4-D-BSA) on SAM of 3-mercaptopropionic acid. With indirect inhibition immunoassay, it demonstrated a low detection limit of 0.1 ppb 2,4-D. Taking advantage of the combination of the SAM technique and immobilization of 2,4-D-BSA at controlled surface coverage, a remarkable enhancement of the low detection limit by 10-fold to 10 ppt with no use of any labels was demonstrated, while keeping the response time constant at 4 min.

本文言語英語
ページ(範囲)1132-1133
ページ数2
ジャーナルChemistry Letters
35
10
DOI
出版ステータス出版済み - 10 5 2006

All Science Journal Classification (ASJC) codes

  • 化学 (全般)

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