Enhancement of cellular glucose uptake by reactive species: A promising approach for diabetes therapy

Naresh Kumar, Priyanka Shaw, Jamoliddin Razzokov, Maksudbek Yusupov, Pankaj Attri, Han Sup Uhm, Eun Ha Choi, Annemie Bogaerts

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

It is generally known that antidiabetic activity is associated with an increased level of glucose uptake in adipocytes and skeletal muscle cells. However, the role of exogenous reactive oxygen and nitrogen species (RONS) in muscle development and more importantly in glucose uptake is largely unknown. We investigate the effect of RONS generated by cold atmospheric plasma (CAP) in glucose uptake. We show that the glucose uptake is significantly enhanced in differentiated L6 skeletal muscle cells after CAP treatment. We also observe a significant increase of the intracellular Ca++ and ROS level, without causing toxicity. One of the possible reasons for an elevated level of glucose uptake as well as intracellular ROS and Ca++ ions is probably the increased oxidative stress leading to glucose transport.

本文言語英語
ページ(範囲)9887-9894
ページ数8
ジャーナルRSC Advances
8
18
DOI
出版ステータス出版済み - 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)
  • 化学工学(全般)

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