Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBPα

Pu Zhang, Junko Iwasaki-Arai, Hiromi Iwasaki, Maris L. Fenyus, Tajhal Dayaram, Bronwyn M. Owens, Hirokazu Shigematsu, Elena Levantini, Claudia S. Huettner, Julie A. Lekstrom-Himes, Koichi Akashi, Daniel G. Tenen

研究成果: Contribution to journalArticle査読

390 被引用数 (Scopus)

抄録

The transcription factor C/EBPα is required for granulopoiesis and frequently disrupted in human acute myeloid leukemia (AML). Here, we show disruption of C/EBPα blocks the transition from the common myeloid to the granulocyte/monocyte progenitor but is not required beyond this stage for terminal granulocyte maturation. C/EBPα-deficient hematopoietic stem cells (HSCs) have increased expression of Bmi-1 and enhanced competitive repopulating activity. Bone marrow in adult C/EBPα-deficient mice was filled with myeloblasts, similar to human AML, supporting the notion that disruption of C/EBPα cooperates with other events in the development of leukemia. Therefore, C/EBPα is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity.

本文言語英語
ページ(範囲)853-863
ページ数11
ジャーナルImmunity
21
6
DOI
出版ステータス出版済み - 12 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 感染症

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