Enhancement of immunoglobulin a production in peyer's patches by oral administration of a traditional chinese medicine, xiao-chai-hu-tang (shosaiko-to)

Yoshihiko Tauchi, Takuva Kawakita, Yuji Saito, Akira Suzuki, Akira Yamada, Yasunobu Yoshikai, Kikuo Nomoto

    研究成果: Contribution to journalArticle査読

    13 被引用数 (Scopus)

    抄録

    The Peyer's patches contain a large number of precursor cells committed to the production of immunoglobulin A (IgA) and play an important role in IgA response in the mucosal immune system. We investigated the induction of IgA producing cells in Peyer's patches by plaque forming cell assay after oral administration of a traditional Chinese herbal medicine, Xiao-chai-hu-tang (Japanese name: Shosaiko-to). The number of total IgA producing cells in the Peyer's patches detected by the protein-A plaque assay was increased about two-fold by Shosaiko-to administration and the numbers of both anti-SRBC and anti-HRBC IgA producing cells were also increased by such a treatment. On the other hand, when SRBC alone were administered orally, only the number of anti-SRBC IgA producing cells was increased. Further, we examined T-cell subpopulations in the gut-associated lymphoid tissues after oral administration of Shosaiko-to by flowcytometry. Marked alternations in T cell subpopulations were not detected in the Peyer's patches, though TcR TcR γdelta;+T-cells in the intraepithelial lymphocytes and Thy 1.2-TcRαbeta;+T cells in the mesenteric lymph nodes were slight increased. These results showed that orally administered Shosaiko-to acts as a polyclonal B-cell activator which induces IgA production in the mucosal immune system.

    本文言語英語
    ページ(範囲)251-272
    ページ数22
    ジャーナルImmunopharmacology and Immunotoxicology
    15
    2-3
    DOI
    出版ステータス出版済み - 1993

    All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学
    • 毒物学
    • 薬理学

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