Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

Lei Wang, Hidenori Okamura, Shigeki Sasaki, Yosuke Taniguchi

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.

本文言語英語
ページ(範囲)9731-9734
ページ数4
ジャーナルChemical Communications
56
67
DOI
出版ステータス出版済み - 8 28 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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