Ent-trachylobane-3β-hydroperoxide, a new diterpene from the root bark of Chrozophora oblongifolia (Fam.; Euphorbiaceae)

Mohamed R. Kamel, Alaa M. Nafady, Ahmed M.M. Hassanein, Ahmed R. Hassan, Kuniyoshi Shimizu, Reham R. Ibrahim, Eman G. Haggag

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

New ent-trachylobane-3β-hydroperoxide (5) together with four known compounds, ricinine (1), trimethoxy ellagic acid (2), dimethoxy ellagic acid (3) and aleurotolic acid (4) were isolated from the methylene chloride fraction of the root bark of Chrozophora oblongifolia. The structures of these secondary metabolites were elucidated by using different spectroscopic techniques, 1H NMR, 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY, HR-ESI-MS, EI-MS and comparison with published data. Ent-trachylobane-3β-hydroperoxide showed moderate cytotoxic activity by MTT assay method against human breast cancer cells (MCF-7) and human hepatocyte-derived carcinoma cells (Huh-7) with IC50 values of 24.53 and 34.13 µM, in comparison with IC50 values of 23.47 µM and 15.82 µM for 5-fluorouracil respectively.

本文言語英語
ページ(範囲)3177-3184
ページ数8
ジャーナルNatural Product Research
35
19
DOI
出版ステータス出版済み - 2021

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 植物科学
  • 有機化学

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