Entrainment of a circadian clock in vitro

Hiroshi Ito, Takuya Yoshida, Yoriko Murayama, Masato Nakajima, Takao Kondo

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Circadian rhythms are the physiological oscillations with about 24 h periods that have period stability under various circumstances. While gene regulatory feedback loop has been proposed for the model of the origin of the circadian oscillation, my colleagues and I had proposed an alternative model. The cyanobacterial circadian clock can be reconstituted in vitro only by mixing the three clock proteins, KaiA, KaiB, and KaiC, with ATP. Namely, the ratio of phosphorylated KaiC oscillates every 24 h in the mixture. This simple biochemical reaction shows self-sustained oscillation like Belosov-Zhabotinsky reaction. Thus, KaiC phosphorylation rhythm can be core oscillator producing cyanobacterial circadian clock. In this paper, I will discuss entrainment of the "in vitro clock" by temperature cycles.

本文言語英語
ホスト出版物のタイトルProceedings of the 15th International Symposium on Artificial Life and Robotics, AROB 15th'10
ページ848-849
ページ数2
出版ステータス出版済み - 12 1 2010
外部発表はい
イベント15th International Symposium on Artificial Life and Robotics, AROB '10 - Beppu, Oita, 日本
継続期間: 2 4 20102 6 2010

出版物シリーズ

名前Proceedings of the 15th International Symposium on Artificial Life and Robotics, AROB 15th'10

その他

その他15th International Symposium on Artificial Life and Robotics, AROB '10
Country日本
CityBeppu, Oita
Period2/4/102/6/10

All Science Journal Classification (ASJC) codes

  • Artificial Intelligence
  • Computer Vision and Pattern Recognition
  • Human-Computer Interaction

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