Enzyme-like chemoselective acylation of alcohols in the presence of amines catalyzed by a tetranuclear zinc cluster

Takashi Ohshima, Takanori Iwasaki, Yusuke Maegawa, Asako Yoshiyama, Kazushi Mashima

研究成果: ジャーナルへの寄稿学術誌査読

145 被引用数 (Scopus)

抄録

Acylation of alcohols and amines is one of the most fundamental reactions. Due to the greater nucleophilicity of the amino group compared to the hydroxyl group, complete N-acylation occurs. Only an enzymatic reaction can promote a highly selective O-acylation reaction, and there are no examples using an artificial catalyst. Here we report that the tetranuclear zinc cluster Zn4(OCOCF3)6O efficiently catalyzes highly chemoselective O-acylation in the presence of primary and secondary alkyl amines. Our results suggest the high potential of the zinc cluster as the core structure of an artificial enzyme to realize further enzyme-like chemoselective reactions.

本文言語英語
ページ(範囲)2944-2945
ページ数2
ジャーナルJournal of the American Chemical Society
130
10
DOI
出版ステータス出版済み - 3月 12 2008
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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