Epidemiological evidence of the relationship between diabetes and dementia

研究成果: 著書/レポートタイプへの貢献

抄録

Growing epidemiological evidence has suggested that subjects with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent. This review examined the risk of dementia in subjects with diabetes mellitus and discusses the possible mechanism underlying this association. Diabetes mellitus is associated with a 1.5- to 2.5-fold greater risk of dementia among community-dwelling elderly people. Notably, diabetes mellitus is a significant risk factor for not only vascular dementia but also Alzheimer’s disease. The mechanisms underlying the association are unclear, but it may be multifactorial in nature, involving factors such as cardiovascular risk factors, glucose toxicity, changes in insulin metabolism, and inflammation. The optimal management of these risk factors in early life may be important to prevent future dementia. Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in subjects with diabetes mellitus.

元の言語英語
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版者Springer New York LLC
ページ13-25
ページ数13
DOI
出版物ステータス出版済み - 1 1 2019

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1128
ISSN(印刷物)0065-2598
ISSN(電子版)2214-8019

Fingerprint

Medical problems
Dementia
Diabetes Mellitus
Independent Living
Vascular Dementia
Metabolism
Toxicity
Alzheimer Disease
Insulin
Inflammation
Glucose

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Ninomiya, T. (2019). Epidemiological evidence of the relationship between diabetes and dementia. : Advances in Experimental Medicine and Biology (pp. 13-25). (Advances in Experimental Medicine and Biology; 巻数 1128). Springer New York LLC. https://doi.org/10.1007/978-981-13-3540-2_2

Epidemiological evidence of the relationship between diabetes and dementia. / Ninomiya, Toshiharu.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 13-25 (Advances in Experimental Medicine and Biology; 巻 1128).

研究成果: 著書/レポートタイプへの貢献

Ninomiya, T 2019, Epidemiological evidence of the relationship between diabetes and dementia. : Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, 巻. 1128, Springer New York LLC, pp. 13-25. https://doi.org/10.1007/978-981-13-3540-2_2
Ninomiya T. Epidemiological evidence of the relationship between diabetes and dementia. : Advances in Experimental Medicine and Biology. Springer New York LLC. 2019. p. 13-25. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-13-3540-2_2
Ninomiya, Toshiharu. / Epidemiological evidence of the relationship between diabetes and dementia. Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. pp. 13-25 (Advances in Experimental Medicine and Biology).
@inbook{51042af5ddce4f2e8a03b612556733a3,
title = "Epidemiological evidence of the relationship between diabetes and dementia",
abstract = "Growing epidemiological evidence has suggested that subjects with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent. This review examined the risk of dementia in subjects with diabetes mellitus and discusses the possible mechanism underlying this association. Diabetes mellitus is associated with a 1.5- to 2.5-fold greater risk of dementia among community-dwelling elderly people. Notably, diabetes mellitus is a significant risk factor for not only vascular dementia but also Alzheimer’s disease. The mechanisms underlying the association are unclear, but it may be multifactorial in nature, involving factors such as cardiovascular risk factors, glucose toxicity, changes in insulin metabolism, and inflammation. The optimal management of these risk factors in early life may be important to prevent future dementia. Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in subjects with diabetes mellitus.",
author = "Toshiharu Ninomiya",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/978-981-13-3540-2_2",
language = "English",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "13--25",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Epidemiological evidence of the relationship between diabetes and dementia

AU - Ninomiya, Toshiharu

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Growing epidemiological evidence has suggested that subjects with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent. This review examined the risk of dementia in subjects with diabetes mellitus and discusses the possible mechanism underlying this association. Diabetes mellitus is associated with a 1.5- to 2.5-fold greater risk of dementia among community-dwelling elderly people. Notably, diabetes mellitus is a significant risk factor for not only vascular dementia but also Alzheimer’s disease. The mechanisms underlying the association are unclear, but it may be multifactorial in nature, involving factors such as cardiovascular risk factors, glucose toxicity, changes in insulin metabolism, and inflammation. The optimal management of these risk factors in early life may be important to prevent future dementia. Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in subjects with diabetes mellitus.

AB - Growing epidemiological evidence has suggested that subjects with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent. This review examined the risk of dementia in subjects with diabetes mellitus and discusses the possible mechanism underlying this association. Diabetes mellitus is associated with a 1.5- to 2.5-fold greater risk of dementia among community-dwelling elderly people. Notably, diabetes mellitus is a significant risk factor for not only vascular dementia but also Alzheimer’s disease. The mechanisms underlying the association are unclear, but it may be multifactorial in nature, involving factors such as cardiovascular risk factors, glucose toxicity, changes in insulin metabolism, and inflammation. The optimal management of these risk factors in early life may be important to prevent future dementia. Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in subjects with diabetes mellitus.

UR - http://www.scopus.com/inward/record.url?scp=85065645710&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065645710&partnerID=8YFLogxK

U2 - 10.1007/978-981-13-3540-2_2

DO - 10.1007/978-981-13-3540-2_2

M3 - Chapter

T3 - Advances in Experimental Medicine and Biology

SP - 13

EP - 25

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -