Epidemiology of multiple sclerosis: environmental factors versus genetic factors

研究成果: ジャーナルへの寄稿評論記事

4 引用 (Scopus)

抄録

Although the mechanism of multiple sclerosis (MS) remains elusive, it is generally hypothesized to be an autoimmune disease targeting the central nervous system (CNS) myelin. Extensive epidemiological and genetic surveys indicate that MS is caused by an interplay between the environment and genetic traits determined by normal polymorphisms in multiple genes. In Japanese, epidemiological surveys gave the prevalence rates of 0.7 to 8.9/100,000. There is a small but significant north-to-south gradient of MS prevalence rates in Japan, suggesting that environmental factors varying with latitude also play a role in developing MS even in the low prevalence areas. Conventional MS in Japanese is, like MS in Caucasians, associated with HLA-DRB1*1501 whereas opticospinal MS is associated with HLA-DPB1*0501. The ratio of conventional to opticospinal MS has increased rapidly in Japanese born after 1960s, suggesting that the modernization occurred after 1960s in Japan has modifying effects on MS susceptibility and phenotypes.

元の言語英語
ページ(範囲)1300-1310
ページ数11
ジャーナルNippon rinsho. Japanese journal of clinical medicine
61
発行部数8
出版物ステータス出版済み - 1 1 2003

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Multiple Sclerosis
Epidemiology
Japan
HLA-DRB1 Chains
Myelin Sheath
Social Change
Autoimmune Diseases
Central Nervous System
Phenotype
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Epidemiology of multiple sclerosis : environmental factors versus genetic factors. / Kira, Jun-Ichi.

:: Nippon rinsho. Japanese journal of clinical medicine, 巻 61, 番号 8, 01.01.2003, p. 1300-1310.

研究成果: ジャーナルへの寄稿評論記事

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abstract = "Although the mechanism of multiple sclerosis (MS) remains elusive, it is generally hypothesized to be an autoimmune disease targeting the central nervous system (CNS) myelin. Extensive epidemiological and genetic surveys indicate that MS is caused by an interplay between the environment and genetic traits determined by normal polymorphisms in multiple genes. In Japanese, epidemiological surveys gave the prevalence rates of 0.7 to 8.9/100,000. There is a small but significant north-to-south gradient of MS prevalence rates in Japan, suggesting that environmental factors varying with latitude also play a role in developing MS even in the low prevalence areas. Conventional MS in Japanese is, like MS in Caucasians, associated with HLA-DRB1*1501 whereas opticospinal MS is associated with HLA-DPB1*0501. The ratio of conventional to opticospinal MS has increased rapidly in Japanese born after 1960s, suggesting that the modernization occurred after 1960s in Japan has modifying effects on MS susceptibility and phenotypes.",
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