Epigenetic events in mammalian germ-cell development: Reprogramming and beyond

Hiroyuki Sasaki, Yasuhisa Matsui

研究成果: Contribution to journalReview article査読

590 被引用数 (Scopus)

抄録

The epigenetic profile of germ cells, which is defined by modifications of DNA and chromatin, changes dynamically during their development. Many of the changes are associated with the acquisition of the capacity to support post-fertilization development. Our knowledge of this aspect has greatly increased - for example, insights into how the re-establishment of parental imprints is regulated. In addition, an emerging theme from recent studies is that epigenetic modifiers have key roles in germ-cell development itself - for example, epigenetics contributes to the gene-expression programme that is required for germ-cell development, regulation of meiosis and genomic integrity. Understanding epigenetic regulation in germ cells has implications for reproductive engineering technologies and human health.

本文言語英語
ページ(範囲)129-140
ページ数12
ジャーナルNature Reviews Genetics
9
2
DOI
出版ステータス出版済み - 2 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)

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