TY - JOUR
T1 - Epigenetic field cancerization in gastrointestinal cancers
AU - Baba, Yoshifumi
AU - Ishimoto, Takatsugu
AU - Kurashige, Junji
AU - Iwatsuki, Masaaki
AU - Sakamoto, Yasuo
AU - Yoshida, Naoya
AU - Watanabe, Masayuki
AU - Baba, Hideo
N1 - Funding Information:
This work was supported in part by a Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research, grant number 26713042 .
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Epigenetic alterations, including aberrant DNA methylation, play an important role in human cancer development. Importantly, epigenetic alterations are reversible and can be targets for therapy or chemoprevention for various types of human cancers. A field for cancerization, or a field defect, is formed by the accumulation of genetic and/or epigenetic alterations in normal-appearing tissues and can correlate with risk of cancer development. Thus, a better understanding of epigenetic field cancerization may represent a useful translational opportunity for cancer risk assessment, including previous history and exposure to carcinogenic factors, and for cancer prevention. In this article, we summarize current knowledge regarding epigenetic field cancerization and its clinical implications in gastrointestinal cancers, including colorectal cancer, gastric cancer and esophageal cancer.
AB - Epigenetic alterations, including aberrant DNA methylation, play an important role in human cancer development. Importantly, epigenetic alterations are reversible and can be targets for therapy or chemoprevention for various types of human cancers. A field for cancerization, or a field defect, is formed by the accumulation of genetic and/or epigenetic alterations in normal-appearing tissues and can correlate with risk of cancer development. Thus, a better understanding of epigenetic field cancerization may represent a useful translational opportunity for cancer risk assessment, including previous history and exposure to carcinogenic factors, and for cancer prevention. In this article, we summarize current knowledge regarding epigenetic field cancerization and its clinical implications in gastrointestinal cancers, including colorectal cancer, gastric cancer and esophageal cancer.
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U2 - 10.1016/j.canlet.2016.03.009
DO - 10.1016/j.canlet.2016.03.009
M3 - Review article
C2 - 26971491
AN - SCOPUS:84962599129
VL - 375
SP - 360
EP - 366
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 2
ER -