Epigenetic field cancerization in gastrointestinal cancers

Yoshifumi Baba; Takatsugu Ishimoto; Junji Kurashige; Masaaki Iwatsuki; Yasuo Sakamoto; Naoya Yoshida; Masayuki Watanabe; Hideo Baba

doi:10.1016/j.canlet.2016.03.009

Epigenetic field cancerization in gastrointestinal cancers

Yoshifumi Baba, Takatsugu Ishimoto, Junji Kurashige, Masaaki Iwatsuki, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba

医学研究院

研究成果: ジャーナルへの寄稿 › 小調査

25 引用（Scopus）

抜粋

Epigenetic alterations, including aberrant DNA methylation, play an important role in human cancer development. Importantly, epigenetic alterations are reversible and can be targets for therapy or chemoprevention for various types of human cancers. A field for cancerization, or a field defect, is formed by the accumulation of genetic and/or epigenetic alterations in normal-appearing tissues and can correlate with risk of cancer development. Thus, a better understanding of epigenetic field cancerization may represent a useful translational opportunity for cancer risk assessment, including previous history and exposure to carcinogenic factors, and for cancer prevention. In this article, we summarize current knowledge regarding epigenetic field cancerization and its clinical implications in gastrointestinal cancers, including colorectal cancer, gastric cancer and esophageal cancer.

元の言語	英語
ページ（範囲）	360-366
ページ数	7
ジャーナル	Cancer Letters
巻	375
発行部数	2
DOI	https://doi.org/10.1016/j.canlet.2016.03.009
出版物ステータス	出版済み - 6 1 2016

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

文献にアクセス

10.1016/j.canlet.2016.03.009

フィンガープリント Epigenetic field cancerization in gastrointestinal cancers' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Baba, Y., Ishimoto, T., Kurashige, J., Iwatsuki, M., Sakamoto, Y., Yoshida, N., Watanabe, M., & Baba, H. (2016). Epigenetic field cancerization in gastrointestinal cancers. Cancer Letters, 375(2), 360-366. https://doi.org/10.1016/j.canlet.2016.03.009

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abstract = "Epigenetic alterations, including aberrant DNA methylation, play an important role in human cancer development. Importantly, epigenetic alterations are reversible and can be targets for therapy or chemoprevention for various types of human cancers. A field for cancerization, or a field defect, is formed by the accumulation of genetic and/or epigenetic alterations in normal-appearing tissues and can correlate with risk of cancer development. Thus, a better understanding of epigenetic field cancerization may represent a useful translational opportunity for cancer risk assessment, including previous history and exposure to carcinogenic factors, and for cancer prevention. In this article, we summarize current knowledge regarding epigenetic field cancerization and its clinical implications in gastrointestinal cancers, including colorectal cancer, gastric cancer and esophageal cancer.",

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AU - Kurashige, Junji

AU - Iwatsuki, Masaaki

AU - Sakamoto, Yasuo

AU - Yoshida, Naoya

AU - Watanabe, Masayuki

AU - Baba, Hideo

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