Epigenetic mechanisms regulating differentiation of neural stem/precursor cells

Aliya Mari D. Adefuin, Ayaka Kimura, Hirofumi Noguchi, Kinichi Nakashima, Masakazu Namihira

研究成果: ジャーナルへの寄稿評論記事

13 引用 (Scopus)

抄録

Differentiation of neural stem/precursor cells (NS/PCs) into neurons, astrocytes and oligodendrocytes during mammalian brain development is a carefully controlled and timed event. Increasing evidences suggest that epigenetic regulation is necessary to drive this. Here, we provide an overview of the epigenetic mechanisms involved in the developing mammalian embryonic forebrain. Histone methylation is a key factor but other epigenetic factors such as DNA methylation and noncoding RNAs also partake during fate determination. As numerous epigenetic modifications have been identified, future studies on timing and regional specificity of these modifications will further deepen our understanding of how intrinsic and extrinsic mechanisms participate together to precisely control brain development.

元の言語英語
ページ(範囲)637-649
ページ数13
ジャーナルEpigenomics
6
発行部数6
DOI
出版物ステータス出版済み - 12 1 2014

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Neural Stem Cells
Epigenomics
Untranslated RNA
Oligodendroglia
Brain
DNA Methylation
Prosencephalon
Astrocytes
Histones
Methylation
Neurons

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

これを引用

Epigenetic mechanisms regulating differentiation of neural stem/precursor cells. / Adefuin, Aliya Mari D.; Kimura, Ayaka; Noguchi, Hirofumi; Nakashima, Kinichi; Namihira, Masakazu.

:: Epigenomics, 巻 6, 番号 6, 01.12.2014, p. 637-649.

研究成果: ジャーナルへの寄稿評論記事

Adefuin, AMD, Kimura, A, Noguchi, H, Nakashima, K & Namihira, M 2014, 'Epigenetic mechanisms regulating differentiation of neural stem/precursor cells', Epigenomics, 巻. 6, 番号 6, pp. 637-649. https://doi.org/10.2217/epi.14.53
Adefuin, Aliya Mari D. ; Kimura, Ayaka ; Noguchi, Hirofumi ; Nakashima, Kinichi ; Namihira, Masakazu. / Epigenetic mechanisms regulating differentiation of neural stem/precursor cells. :: Epigenomics. 2014 ; 巻 6, 番号 6. pp. 637-649.
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