Epigenetic mechanisms regulating fate specification of neural stem cells

Masakazu Namihira, Jun Kohyama, Masahiko Abematsu, Kinichi Nakashima

研究成果: Contribution to journalReview article査読

61 被引用数 (Scopus)

抄録

Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. These processes are defined by the dynamic interplay between extracellular cues including cytokine signalling and intracellular programmes such as epigenetic modification. There is increasing evidence that epigenetic mechanisms involving, for example, changes in DNA methylation, histone modification and non-coding RNA expression are closely associated with fate specification of NSCs. These epigenetic alterations could provide coordinated systems for regulating gene expression at each step of neural cell differentiation. Here we review the roles of epigenetics in neural fate specification in the mammalian central nervous system.

本文言語英語
ページ(範囲)2099-2109
ページ数11
ジャーナルPhilosophical Transactions of the Royal Society B: Biological Sciences
363
1500
DOI
出版ステータス出版済み - 6 27 2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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