Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development

Takumi Nakagawa, Yoshikuni Wada, Sayako Katada, Yusuke Kishi

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

The nervous system consists of several hundred neuronal subtypes and glial cells that show specific gene expression and are generated from common ancestors, neural stem cells (NSCs). As the experimental techniques and molecular tools to analyze epigenetics and chromatin structures are rapidly advancing, the comprehensive events and genome-wide states of DNA methylation, histone modifications, and chromatin accessibility in developing NSCs are gradually being unveiled. Here, we review recent advances in elucidating the role of epigenetic and chromatin regulation in NSCs, especially focusing on the acquisition of glial identity and how epigenetic regulation enables the temporal regulation of NSCs during murine cortical development.

本文言語英語
ページ(範囲)1554-1567
ページ数14
ジャーナルGLIA
68
8
DOI
出版ステータス出版済み - 8 1 2020

All Science Journal Classification (ASJC) codes

  • 神経学
  • 細胞および分子神経科学

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