Epigenetic regulation of drug transporter expression in human tissues

Takeshi Hirota, Toshihiro Tanaka, Hiroaki Takesue, Ichiro Ieiri

研究成果: Contribution to journalReview article査読

7 被引用数 (Scopus)

抄録

Introduction: Drug transporters are expressed in a number of tissues such as the intestine, liver, and kidney, and play key roles in drug absorption, distribution, and excretion. Variations in drug transporter gene expression significantly contribute to interindividual differences in drug responses. Epigenetic regulation of drug transporter genes has recently emerged as an important mechanism. Epigenetic regulation alters the expression of genes without changing DNA sequences. Epigenetic control mechanisms are associated with DNA methylation, histone modifications, and microRNAs. Herein we discuss recent advances in the study of the transcriptional and post-transcriptional mechanisms of drug transporters with a focus on epigenetic regulation. Areas covered: This review summarizes recent research on the epigenetic regulation of drug transporter genes, and highlights the importance of identifying novel biomarkers based on epigenetics for use in individualized drug therapy. Expert opinion: Researchers are actively attempting to elucidate the epigenetic mechanisms that control the expression of drug transporters, which affect the pharmacokinetics of drugs. Current evidence suggests that epigenetic changes play an important role in drug transporter function. A clearer understanding of epigenetic regulation in drug transporter genes will provide an insight into novel approaches to individualized drug therapy.

本文言語英語
ページ(範囲)19-30
ページ数12
ジャーナルExpert Opinion on Drug Metabolism and Toxicology
13
1
DOI
出版ステータス出版済み - 1 2 2017

All Science Journal Classification (ASJC) codes

  • 毒物学
  • 薬理学

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