Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration

研究成果: ジャーナルへの寄稿評論記事

6 引用 (Scopus)

抄録

Severe spinal cord injury (SCI) leads to almost complete neural cell loss at the injured site, causing the irreversible disruption of neuronal circuits. The transplantation of neural stem or precursor cells (NS/PCs) has been regarded as potentially effective for SCI treatment because NS/PCs can compensate for the injured sites by differentiating into neurons and glial cells (astrocytes and oligodendrocytes). An understanding of the molecular mechanisms that regulate the proliferation, fate specification and maturation of NS/PCs and their progeny would facilitate the establishment of better therapeutic strategies for regeneration after SCI. In recent years, several studies of SCI animal models have demonstrated that the modulation of specific epigenetic marks by histone modifiers and non-coding RNAs directs the setting of favorable cellular environments that promote the neuronal differentiation of NS/PCs and/or the elongation of the axons of the surviving neurons at the injured sites. In this review, we provide an overview of recent progress in the epigenetic regulation/manipulation of neural cells for the treatment of SCI.

元の言語英語
ページ(範囲)189-199
ページ数11
ジャーナルCell and tissue research
371
発行部数1
DOI
出版物ステータス出版済み - 1 1 2018

Fingerprint

Spinal Cord Regeneration
Neural Stem Cells
Epigenomics
Cell Differentiation
Spinal Cord Injuries
Histone Code
Neurons
Untranslated RNA
Oligodendroglia
Neuroglia
Astrocytes
Axons
Regeneration
Animal Models
Transplantation

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

これを引用

Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration. / Kameda, Tomonori; Imamura, Takuya; Nakashima, Kinichi.

:: Cell and tissue research, 巻 371, 番号 1, 01.01.2018, p. 189-199.

研究成果: ジャーナルへの寄稿評論記事

@article{556276cd6e3940a6a903a9ef428e3fa1,
title = "Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration",
abstract = "Severe spinal cord injury (SCI) leads to almost complete neural cell loss at the injured site, causing the irreversible disruption of neuronal circuits. The transplantation of neural stem or precursor cells (NS/PCs) has been regarded as potentially effective for SCI treatment because NS/PCs can compensate for the injured sites by differentiating into neurons and glial cells (astrocytes and oligodendrocytes). An understanding of the molecular mechanisms that regulate the proliferation, fate specification and maturation of NS/PCs and their progeny would facilitate the establishment of better therapeutic strategies for regeneration after SCI. In recent years, several studies of SCI animal models have demonstrated that the modulation of specific epigenetic marks by histone modifiers and non-coding RNAs directs the setting of favorable cellular environments that promote the neuronal differentiation of NS/PCs and/or the elongation of the axons of the surviving neurons at the injured sites. In this review, we provide an overview of recent progress in the epigenetic regulation/manipulation of neural cells for the treatment of SCI.",
author = "Tomonori Kameda and Takuya Imamura and Kinichi Nakashima",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s00441-017-2656-2",
language = "English",
volume = "371",
pages = "189--199",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration

AU - Kameda, Tomonori

AU - Imamura, Takuya

AU - Nakashima, Kinichi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Severe spinal cord injury (SCI) leads to almost complete neural cell loss at the injured site, causing the irreversible disruption of neuronal circuits. The transplantation of neural stem or precursor cells (NS/PCs) has been regarded as potentially effective for SCI treatment because NS/PCs can compensate for the injured sites by differentiating into neurons and glial cells (astrocytes and oligodendrocytes). An understanding of the molecular mechanisms that regulate the proliferation, fate specification and maturation of NS/PCs and their progeny would facilitate the establishment of better therapeutic strategies for regeneration after SCI. In recent years, several studies of SCI animal models have demonstrated that the modulation of specific epigenetic marks by histone modifiers and non-coding RNAs directs the setting of favorable cellular environments that promote the neuronal differentiation of NS/PCs and/or the elongation of the axons of the surviving neurons at the injured sites. In this review, we provide an overview of recent progress in the epigenetic regulation/manipulation of neural cells for the treatment of SCI.

AB - Severe spinal cord injury (SCI) leads to almost complete neural cell loss at the injured site, causing the irreversible disruption of neuronal circuits. The transplantation of neural stem or precursor cells (NS/PCs) has been regarded as potentially effective for SCI treatment because NS/PCs can compensate for the injured sites by differentiating into neurons and glial cells (astrocytes and oligodendrocytes). An understanding of the molecular mechanisms that regulate the proliferation, fate specification and maturation of NS/PCs and their progeny would facilitate the establishment of better therapeutic strategies for regeneration after SCI. In recent years, several studies of SCI animal models have demonstrated that the modulation of specific epigenetic marks by histone modifiers and non-coding RNAs directs the setting of favorable cellular environments that promote the neuronal differentiation of NS/PCs and/or the elongation of the axons of the surviving neurons at the injured sites. In this review, we provide an overview of recent progress in the epigenetic regulation/manipulation of neural cells for the treatment of SCI.

UR - http://www.scopus.com/inward/record.url?scp=85022184568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85022184568&partnerID=8YFLogxK

U2 - 10.1007/s00441-017-2656-2

DO - 10.1007/s00441-017-2656-2

M3 - Review article

C2 - 28695279

AN - SCOPUS:85022184568

VL - 371

SP - 189

EP - 199

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 1

ER -