Epigenetic regulation of neural stem cell fate during corticogenesis

Chai MuhChyi, Berry Juliandi, Taito Matsuda, Kinichi Nakashima

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

抄録

The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.

元の言語英語
ページ(範囲)424-433
ページ数10
ジャーナルInternational Journal of Developmental Neuroscience
31
発行部数6
DOI
出版物ステータス出版済み - 10 1 2013

Fingerprint

Neural Stem Cells
Epigenomics
Cerebral Cortex
Multipotent Stem Cells
Intrinsic Factor
Neural Tube
Neurogenesis
Cognition
Cell Differentiation
Cell Line
Brain

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

これを引用

Epigenetic regulation of neural stem cell fate during corticogenesis. / MuhChyi, Chai; Juliandi, Berry; Matsuda, Taito; Nakashima, Kinichi.

:: International Journal of Developmental Neuroscience, 巻 31, 番号 6, 01.10.2013, p. 424-433.

研究成果: ジャーナルへの寄稿記事

@article{2f3117f8f0a84bc4b9ef04fee8348a5c,
title = "Epigenetic regulation of neural stem cell fate during corticogenesis",
abstract = "The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.",
author = "Chai MuhChyi and Berry Juliandi and Taito Matsuda and Kinichi Nakashima",
year = "2013",
month = "10",
day = "1",
doi = "10.1016/j.ijdevneu.2013.02.006",
language = "English",
volume = "31",
pages = "424--433",
journal = "International Journal of Developmental Neuroscience",
issn = "0736-5748",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Epigenetic regulation of neural stem cell fate during corticogenesis

AU - MuhChyi, Chai

AU - Juliandi, Berry

AU - Matsuda, Taito

AU - Nakashima, Kinichi

PY - 2013/10/1

Y1 - 2013/10/1

N2 - The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.

AB - The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.

UR - http://www.scopus.com/inward/record.url?scp=84880037175&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880037175&partnerID=8YFLogxK

U2 - 10.1016/j.ijdevneu.2013.02.006

DO - 10.1016/j.ijdevneu.2013.02.006

M3 - Article

C2 - 23466416

AN - SCOPUS:84880037175

VL - 31

SP - 424

EP - 433

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

SN - 0736-5748

IS - 6

ER -