Epigenetic regulation of neural stem cell property from embryo to adult

Naoya Murao, Hirofumi Noguchi, Kinichi Nakashima

研究成果: ジャーナルへの寄稿総説査読

30 被引用数 (Scopus)

抄録

Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This multipotency is acquired by NSCs during development and is maintained throughout life. Proliferation, fate specification, and maturation of NSCs are regulated by both cell intrinsic and extrinsic factors. Epigenetic modification is a representative intrinsic factor, being involved in many biological aspects of central nervous system development and adult neurogenesis through the regulation of NSC dynamics. In this review, we summarize recent progress in the epigenetic regulation of NSC behavior in the embryonic and adult brain, with particular reference to DNA methylation, histone modification, and noncoding RNAs.

本文言語英語
ページ(範囲)1-10
ページ数10
ジャーナルNeuroepigenetics
5
DOI
出版ステータス出版済み - 1月 1 2016

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 発達神経科学
  • 認知神経科学
  • 細胞および分子神経科学
  • 生物学的精神医学

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