Epithelial-to-mesenchymal transition–based morphogenesis of dorsal mesentery and gonad

研究成果: ジャーナルへの寄稿総説査読

9 被引用数 (Scopus)


Dorsal mesentery and gonad (ovary and testis) are formed in distinct regions of the body and have different characteristics. Recent studies using chicken embryos showed that progenitors of these two organs are derived from the coelomic lining region, a ventral part of the medial lateral plate mesoderm (M-LPM). Furthermore, both types of progenitors develop in a similar manner, concomitant with morphological changes termed the epithelial-to-mesenchymal transition (EMT). EMT processes in both dorsal mesentery and gonad formation are regulated by BMP signaling. Interestingly, EMT-based morphogenetic events occur repetitively at M-LPM specification before dorsal mesenteric and gonadal formation, at ovary formation later in embryogenesis, and even during adult ovary repair. We review recent findings related to EMT-based morphogenesis and the governing molecular mechanisms, mainly in early dorsal mesenteric and gonadal formation, as well as in their anlages and derivatives.

ジャーナルSeminars in Cell and Developmental Biology
出版ステータス出版済み - 8月 2019

!!!All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学


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