Epstein–Barr virus-positive diffuse large B-cell lymphoma following acute myeloid leukemia: a common clonal origin indicated by chromosomal translocation t(3;4)(p25;q21)

Masakazu Higuchi, Shoichi Sasaki, Shin ichiro Kawadoko, Hikaru Uchiyama, Takaharu Yasui, Takashi Kamihira, Ken ichi Aoki, Takakazu Sasaguri, Ryuji Nakano, Akihiko Uchiyama, Tsuyoshi Muta, Koichi Ohshima

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Secondary non-Hodgkin lymphoma following acute myeloid leukemia (AML) is extremely rare. We here describe a unique case involving a patient who developed Epstein–Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) during complete remission (CR) of AML. A 75-year-old Japanese man was initially diagnosed with AML with maturation (FAB M2), bearing chromosomal translocation t(3,4)(p25;q21). After intensive chemotherapy, bone marrow aspiration revealed normal karyotype, and he achieved CR. Six years and 4 months later, he was still in CR from AML, but developed DLBCL presenting in the terminal ileum. Cytogenetic analysis of the DLBCL cells showed the same translocation as the previous AML. The rearrangements of the immunoglobulin heavy chain genes of the two malignancies were examined using polymerase chain reaction amplification, and the rearrangement patterns were found to differ from each other. Our data thus suggest that, in the present case, the AML and DLBCL arose from a common progenitor cell, as indicated by the clonal abnormality t(3,4)(p25;q21), and that different immunoglobulin heavy chain gene rearrangements occurred during each course of clonal evolution.

本文言語英語
ページ(範囲)482-487
ページ数6
ジャーナルInternational journal of hematology
102
4
DOI
出版ステータス出版済み - 10 1 2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 血液学

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