Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development

Xiaohong Song, Yuya Sato, Kiyotoshi Sekiguchi, Hideaki Tanaka, Kunimasa Ohta

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)


Background: Adhesion molecules are known to be instructive for both development and differentiation. During lens differentiation, epithelial cells undergo vertical elongation, with the anterior and posterior tips of the elongating fiber cells sliding along the epithelium and capsule, respectively. These cellular processes are highly coordinated through cell adhesive interactions, actin cytoskeletal reorganization and contractile force generation. Alterations in extracellular matrix composition that interfere with these interactions can lead to defects that alter tissue morphogenesis and the state of differentiation. We have demonstrated that Equarin, which is a secreted molecule expressed in the equator region of the lens, plays an important role in chick lens fiber differentiation through fibroblast growth factor signaling. Results: Here, we explored the function of Equarin in chick lens cell adhesion. Equarin protein was expressed in the extracellular region of lens differentiating cells. We found that Equarin promoted lens cell adhesion through heparan sulfate proteoglycan. By biochemical analysis, we found that Equarin directly binds syndecan-3, which displayed a similar expression pattern to Equarin. Overexpression of Equarin resulted in altered actin localization. Conclusions: Equarin is involved in cell adhesion during fiber differentiation and development.

ジャーナルDevelopmental Dynamics
出版ステータス出版済み - 1月 1 2013

!!!All Science Journal Classification (ASJC) codes

  • 発生生物学


「Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。