Escherichia coli O8:H8 Carrying a novel variant of the heat-labile enterotoxin LT2 gene caused outbreaks of diarrhea

Kai Ishimaru, Mari Sasaki, Hiroshi Narimatsu, Yoko Arimizu, Yasuhiro Gotoh, Keiji Nakamura, Tetsuya Hayashi, Yoshitoshi Ogura

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

No outbreaks caused by Escherichia coli-producing heat-labile enterotoxin LT2 have been reported to date. Here, we revealed that the E. coli O8:H8 strains isolated from patients in 2 independent diarrhea outbreaks were negative for any known virulence determinants in routine microbiological tests, were very closely related, and carried a prophage-encoded gene for a novel LT2 variant (LT2d) and the genes for colonization factor antigen III. We also showed that LT2d has a cytotonic activity similar to LT1. These data indicate the importance of E. coli strains producing LT2d as a human pathogen.

本文言語英語
ジャーナルOpen Forum Infectious Diseases
7
1
DOI
出版ステータス出版済み - 1 1 2020

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 臨床神経学

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