TY - JOUR
T1 - Essential Oils Derived from Cistus Species Activate Mitochondria by Inducing SIRT1 Expression in Human Keratinocytes, Leading to Senescence Inhibition
AU - Ledrhem, Merieme
AU - Nakamura, Miku
AU - Obitsu, Miyu
AU - Hirae, Kinue
AU - Kameyama, Jun
AU - Bouamama, Hafida
AU - Gadhi, Chemseddoha
AU - Katakura, Yoshinori
N1 - Funding Information:
Funding: This research was funded by the Japan International Cooperation Agency (JICA)–Japan Science and Technology Agency (JST)’s Science and Technology Research Partnership for Sustainable Development (SATREPS) project entitled “Valorization of Bioresources Based on Scientific Evidence in Semi-and Arid Land for Creation of New Industry” (Grant No. JPMJSA1506) and by the Ministry of Higher Education, Scientific Research and Executive Training (MHESRET) of Kingdom of Morocco.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Cistus L. is a genus of dicotyledonous perennial herbaceous plants. Cistus species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from Cistus species (Cistus laurifolius, C. monspeliensis, C. creticus, and C. salviifolius) were evaluated. Essential oils derived from C. laurifolius and C. monspeliensis were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up-and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from C. laurifolius and C. monspeliensis may inhibit skin aging through mitochondrial regulation via SIRT1 activation.
AB - Cistus L. is a genus of dicotyledonous perennial herbaceous plants. Cistus species have been commonly used in folk medicine in the Mediterranean region. In the present study, the biological activities of essential oils derived from Cistus species (Cistus laurifolius, C. monspeliensis, C. creticus, and C. salviifolius) were evaluated. Essential oils derived from C. laurifolius and C. monspeliensis were found to augment the expression of SIRT1, an anti-aging gene, in the normal culture of HaCaT cells. Furthermore, these essential oils increased the number and size of mitochondria and augmented their activity. These effects were thought to be caused by the up-and downregulated expression of MITOL and Drp1 in HaCaT cells, respectively, in response to the essential oil treatment. In addition, these essential oils were found to attenuate ultraviolet-B-induced mitochondrial damage and cellular senescence in HaCaT cells. These findings indicate that essential oils derived from C. laurifolius and C. monspeliensis may inhibit skin aging through mitochondrial regulation via SIRT1 activation.
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U2 - 10.3390/molecules27072053
DO - 10.3390/molecules27072053
M3 - Article
C2 - 35408452
AN - SCOPUS:85127484798
SN - 1420-3049
VL - 27
JO - Molecules
JF - Molecules
IS - 7
M1 - 2053
ER -