Establishment and characterization of a novel primitive yolk sac tumour cell line, TC587

Takeshi Iwasaki, Kenichi Kohashi, Masasuke Ohno, Tomoaki Taguchi, Yoshinao Oda

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Background/Aim: Yolk sac tumour (YST) is a rare malignant ovarian germ cell tumour that often occurs in young women or adolescents and exhibits an unfavourable outcome. To evaluate the biological behavior of carcinomas in vitro, permanent tumour cell lines are required. However, previously, only a few human YST cell lines have been established. Therefore, we aimed to establish a novel YST cell line. Materials and Methods: We established a novel YST cell line, TC587, from an adolescent patient with ovarian YST. Results: The cell line expressed AFP and SALL4, the characteristics of YST. In addition, we evaluated somatic mutations using nextgeneration sequencing and revealed some pathogenic variants, including mutations in the NRAS, KIT, KMT2C, RSF1, and TP53 genes. Conclusion: The newly established TC587 cell line may represent an effective tool for developing treatments and conducting molecular analyses for YST.

本文言語英語
ページ(範囲)759-766
ページ数8
ジャーナルAnticancer research
40
2
DOI
出版ステータス出版済み - 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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