抜粋
Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-2 vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 33-39 |
| ページ数 | 7 |
| ジャーナル | International journal of oncology |
| 巻 | 5 |
| 発行部数 | 1 |
| 出版物ステータス | 出版済み - 1 1 1994 |
フィンガープリント
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research
これを引用
Nishi, Y., Haji, M., Takayanagi, R., Iguchi, H., Shimazoe, T., Hirata, J., & Nawata, H. (1994). Establishment and characterization of PTHrP-producing human pancreatic cancer cell line. International journal of oncology, 5(1), 33-39.