Estimation of the performance of a PUF/spheroid packed-bed type artificial liver by using an extracorporeal circulation with hepatic failure rats

T. Matsushita, Hiroyuki Ijima, Shin-Ichiro Wada, K. Funatsu

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

抄録

Multicapillary (MC) polyurethane foam (PUF)/spheroid packed-bed type artificial liver was applied to cure D-galactosamine induced hepatic failure rats (PT value; 27-43 [s] in failure, ;19-20 [s] in normal) with an extracorporeal circulation for 3 hours, which connected with the carotid artery and jugular vein (n=5). In 4 cases of the experiments, the increasing of the blood ammonia concentrations were suppressed under hepatic coma level (196 N-μg/dl) and the concentrations decreased at normal level within 40 hours. The increased PT, GPT, GOT, total bilirubin, and total bile acid concentrations in the blood also decreased at normal level within 4 days, and these rats were recovered from hepatic failure. On the contrary, when MC-PUF packed-bed without hepatocytes were applied to the hepatic failure rats (n=3, control experiments), the blood ammonia concentrations rapidly increased more than hepatic coma level (196 N-μg/dl) in all cases and these rats were died. From these results, it was suggested that hepatocytes/spheroid in the artificial liver could detoxify the blood ammonia, and had some important roles for recovery from D-gal induced hepatic failure.

元の言語英語
ページ(範囲)815-820
ページ数6
ジャーナルJapanese Journal of Artificial Organs
24
発行部数3
出版物ステータス出版済み - 1 1 1995

Fingerprint

Artificial Liver
Extracorporeal Circulation
Liver Failure
Ammonia
Hepatic Encephalopathy
Hepatocytes
Galactosamine
Jugular Veins
Bile Acids and Salts
Carotid Arteries
Bilirubin
polyurethane foam

All Science Journal Classification (ASJC) codes

  • Biophysics

これを引用

Estimation of the performance of a PUF/spheroid packed-bed type artificial liver by using an extracorporeal circulation with hepatic failure rats. / Matsushita, T.; Ijima, Hiroyuki; Wada, Shin-Ichiro; Funatsu, K.

:: Japanese Journal of Artificial Organs, 巻 24, 番号 3, 01.01.1995, p. 815-820.

研究成果: ジャーナルへの寄稿記事

@article{6d4d95e3712c416bb27e23b01f2c2ce9,
title = "Estimation of the performance of a PUF/spheroid packed-bed type artificial liver by using an extracorporeal circulation with hepatic failure rats",
abstract = "Multicapillary (MC) polyurethane foam (PUF)/spheroid packed-bed type artificial liver was applied to cure D-galactosamine induced hepatic failure rats (PT value; 27-43 [s] in failure, ;19-20 [s] in normal) with an extracorporeal circulation for 3 hours, which connected with the carotid artery and jugular vein (n=5). In 4 cases of the experiments, the increasing of the blood ammonia concentrations were suppressed under hepatic coma level (196 N-μg/dl) and the concentrations decreased at normal level within 40 hours. The increased PT, GPT, GOT, total bilirubin, and total bile acid concentrations in the blood also decreased at normal level within 4 days, and these rats were recovered from hepatic failure. On the contrary, when MC-PUF packed-bed without hepatocytes were applied to the hepatic failure rats (n=3, control experiments), the blood ammonia concentrations rapidly increased more than hepatic coma level (196 N-μg/dl) in all cases and these rats were died. From these results, it was suggested that hepatocytes/spheroid in the artificial liver could detoxify the blood ammonia, and had some important roles for recovery from D-gal induced hepatic failure.",
author = "T. Matsushita and Hiroyuki Ijima and Shin-Ichiro Wada and K. Funatsu",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "24",
pages = "815--820",
journal = "Japanese Journal of Artificial Organs",
issn = "0300-0818",
publisher = "Japanese Society for Artificial Organs and Tissues",
number = "3",

}

TY - JOUR

T1 - Estimation of the performance of a PUF/spheroid packed-bed type artificial liver by using an extracorporeal circulation with hepatic failure rats

AU - Matsushita, T.

AU - Ijima, Hiroyuki

AU - Wada, Shin-Ichiro

AU - Funatsu, K.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Multicapillary (MC) polyurethane foam (PUF)/spheroid packed-bed type artificial liver was applied to cure D-galactosamine induced hepatic failure rats (PT value; 27-43 [s] in failure, ;19-20 [s] in normal) with an extracorporeal circulation for 3 hours, which connected with the carotid artery and jugular vein (n=5). In 4 cases of the experiments, the increasing of the blood ammonia concentrations were suppressed under hepatic coma level (196 N-μg/dl) and the concentrations decreased at normal level within 40 hours. The increased PT, GPT, GOT, total bilirubin, and total bile acid concentrations in the blood also decreased at normal level within 4 days, and these rats were recovered from hepatic failure. On the contrary, when MC-PUF packed-bed without hepatocytes were applied to the hepatic failure rats (n=3, control experiments), the blood ammonia concentrations rapidly increased more than hepatic coma level (196 N-μg/dl) in all cases and these rats were died. From these results, it was suggested that hepatocytes/spheroid in the artificial liver could detoxify the blood ammonia, and had some important roles for recovery from D-gal induced hepatic failure.

AB - Multicapillary (MC) polyurethane foam (PUF)/spheroid packed-bed type artificial liver was applied to cure D-galactosamine induced hepatic failure rats (PT value; 27-43 [s] in failure, ;19-20 [s] in normal) with an extracorporeal circulation for 3 hours, which connected with the carotid artery and jugular vein (n=5). In 4 cases of the experiments, the increasing of the blood ammonia concentrations were suppressed under hepatic coma level (196 N-μg/dl) and the concentrations decreased at normal level within 40 hours. The increased PT, GPT, GOT, total bilirubin, and total bile acid concentrations in the blood also decreased at normal level within 4 days, and these rats were recovered from hepatic failure. On the contrary, when MC-PUF packed-bed without hepatocytes were applied to the hepatic failure rats (n=3, control experiments), the blood ammonia concentrations rapidly increased more than hepatic coma level (196 N-μg/dl) in all cases and these rats were died. From these results, it was suggested that hepatocytes/spheroid in the artificial liver could detoxify the blood ammonia, and had some important roles for recovery from D-gal induced hepatic failure.

UR - http://www.scopus.com/inward/record.url?scp=0029076494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029076494&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0029076494

VL - 24

SP - 815

EP - 820

JO - Japanese Journal of Artificial Organs

JF - Japanese Journal of Artificial Organs

SN - 0300-0818

IS - 3

ER -