Estrous-cycle-dependent variation in orthodontic tooth movement

Naoto Haruyama, K. Igarashi, S. Saeki, M. Otsuka-Isoya, H. Shinoda, H. Mitani

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

抄録

Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = 0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.

元の言語英語
ページ(範囲)406-410
ページ数5
ジャーナルJournal of Dental Research
81
発行部数6
DOI
出版物ステータス出版済み - 1 1 2002
外部発表Yes

Fingerprint

Tooth Movement Techniques
Estrous Cycle
Estrus
Estradiol
Gonadal Steroid Hormones
Bone Resorption
Orthodontics
Serum
Wistar Rats
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

これを引用

Haruyama, N., Igarashi, K., Saeki, S., Otsuka-Isoya, M., Shinoda, H., & Mitani, H. (2002). Estrous-cycle-dependent variation in orthodontic tooth movement. Journal of Dental Research, 81(6), 406-410. https://doi.org/10.1177/154405910208100610

Estrous-cycle-dependent variation in orthodontic tooth movement. / Haruyama, Naoto; Igarashi, K.; Saeki, S.; Otsuka-Isoya, M.; Shinoda, H.; Mitani, H.

:: Journal of Dental Research, 巻 81, 番号 6, 01.01.2002, p. 406-410.

研究成果: ジャーナルへの寄稿記事

Haruyama, N, Igarashi, K, Saeki, S, Otsuka-Isoya, M, Shinoda, H & Mitani, H 2002, 'Estrous-cycle-dependent variation in orthodontic tooth movement', Journal of Dental Research, 巻. 81, 番号 6, pp. 406-410. https://doi.org/10.1177/154405910208100610
Haruyama, Naoto ; Igarashi, K. ; Saeki, S. ; Otsuka-Isoya, M. ; Shinoda, H. ; Mitani, H. / Estrous-cycle-dependent variation in orthodontic tooth movement. :: Journal of Dental Research. 2002 ; 巻 81, 番号 6. pp. 406-410.
@article{852877d66f9c4e9a832235bf7bb58f1c,
title = "Estrous-cycle-dependent variation in orthodontic tooth movement",
abstract = "Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33{\%} greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = 0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.",
author = "Naoto Haruyama and K. Igarashi and S. Saeki and M. Otsuka-Isoya and H. Shinoda and H. Mitani",
year = "2002",
month = "1",
day = "1",
doi = "10.1177/154405910208100610",
language = "English",
volume = "81",
pages = "406--410",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Estrous-cycle-dependent variation in orthodontic tooth movement

AU - Haruyama, Naoto

AU - Igarashi, K.

AU - Saeki, S.

AU - Otsuka-Isoya, M.

AU - Shinoda, H.

AU - Mitani, H.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = 0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.

AB - Sex hormones, including estradiol, play important physiological roles in bone metabolism. The purpose of this study was to investigate whether there is estrous-cycle-dependent variation in orthodontic tooth movement, and, if so, to determine the mechanism. Ten-week-old female Wistar rats were used. They received repeated orthodontic force during specific phases in the estrous cycle. Tooth movement in animals that received force principally in estrus was about 33% greater than that in animals that received such force principally in pro-estrus (p < 0.05). Serum estradiol levels also varied according to the estrous cycle, with a peak during pro-estrus and a nadir during estrus, and were inversely related to tooth movement. Furthermore, there were negative correlations between estradiol and both serum TRAP activity and pyridinoline (r = -0.42, p < 0.05; r = 0.59, p < 0.001). These results suggest that cyclic changes in the estradiol level may be associated with the estrous-cycle-dependent variation in tooth movement through its effects on bone resorption.

UR - http://www.scopus.com/inward/record.url?scp=0035983428&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035983428&partnerID=8YFLogxK

U2 - 10.1177/154405910208100610

DO - 10.1177/154405910208100610

M3 - Article

C2 - 12097433

AN - SCOPUS:0035983428

VL - 81

SP - 406

EP - 410

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 6

ER -