Etiology and molecular biology of hyperproinsulinemia

N. Nakashima, F. Umeda

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

Clinical hyperproinsulinemia occurs not only in familial hyperproinsulinemia, but also in insulinoma, renal failure, and even in non-insulin-dependent diabetes mellitus (NIDDM). The etiology of hyperproinsulinemia is divided into (1) abnormality of pro-insulin molecules, (2) abnormality of pancreatic beta-cells other than proinsulin molecules, (3) retardation of proinsulin clearance. Hyperproinsulinemia is now thought to be both a result of the above-mentioned diseases and a cause of atherosclerosis in patients with NIDDM. Recent developments in molecular biology have deepened our knowledge of the biosynthesis and role of proinsulin, especially the prohormone sorting mechanism into secretory granules in pancreatic beta-cells.

本文言語英語
ページ(範囲)2556-2561
ページ数6
ジャーナルNippon rinsho. Japanese journal of clinical medicine
52
10
出版ステータス出版済み - 10 1994

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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