Evaluating the performance of a hybrid artificial liver support system with a recoverable hepatic failure rat model

Hiroyuki Ijima, Ayako Noguchi, Takeyuki Katsuno, Tsutomu Ono, Kohji Nakazawa, Kazumori Funatsu, Koei Kawakami

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

To evaluate the performance of an artificial liver, we created a recoverable hepatic failure rat model. This involves a 30-60 minute warm ischemia, via clamping, of one-third of the liver with a partial (two-thirds) hepatectomy. Variations on this method provide for the possibility of several modes of hepatic failure. Survival time of the rats was prolonged (35%) by applying our hybrid artificial liver. However, the extracorporeal circulation is a considerable burden to the rat. Therefore, we need to apply the hybrid artificial liver intermittently and repeatedly.

本文言語英語
ページ(範囲)344-349
ページ数6
ジャーナルAnnals of the New York Academy of Sciences
944
DOI
出版ステータス出版済み - 1 1 2001

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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