Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

Noriyuki Sonoda, Toyoshi Inoguchi, Yohei Minami, Fuminori Hyodo, Kazuhiro Ichikawa, Mayumi Yamato, Hideo Utsumi, Ryoichi Takayanagi

研究成果: Contribution to journalReview article査読

1 被引用数 (Scopus)

抄録

Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not fully understood. We have evaluated brain redox status and its association of cognitive dysfunction in diabetic animal models by dynamic nuclear polarization-magnetic resonance imaging (DNP-MRI) and other oxidative stress markers. In this review, we discuss the role of oxidative stress in the development of diabetes-related dementia and clinical regulation of the redox state in new approaches to augmenting diabetes-related dementia.

本文言語英語
ページ(範囲)1081-1086
ページ数6
ジャーナルYakugaku Zasshi
136
8
DOI
出版ステータス出版済み - 2016

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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