Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell

Kentaro Nishi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We succeeded in developing novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic peptide side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and evaluated in vitro.

元の言語英語
ホスト出版物のタイトル55th SPSJ Symposium on Macromolecules
ページ5461-5462
ページ数2
55
エディション2
出版物ステータス出版済み - 2006
イベント55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本
継続期間: 9 20 20069 22 2006

その他

その他55th Society of Polymer Science Japan Symposium on Macromolecules
日本
Toyama
期間9/20/069/22/06

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Cells
Copolymers
Micelles
Substrates
Collagen
Peptides
Bone
Metalloproteases
Polymers

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Nishi, K., Mori, T., Niidome, T., & Katayama, Y. (2006). Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell. : 55th SPSJ Symposium on Macromolecules (2 版, 巻 55, pp. 5461-5462)

Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell. / Nishi, Kentaro; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki.

55th SPSJ Symposium on Macromolecules. 巻 55 2. 編 2006. p. 5461-5462.

研究成果: 著書/レポートタイプへの貢献会議での発言

Nishi, K, Mori, T, Niidome, T & Katayama, Y 2006, Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell. : 55th SPSJ Symposium on Macromolecules. 2 Edn, 巻. 55, pp. 5461-5462, 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 日本, 9/20/06.
Nishi K, Mori T, Niidome T, Katayama Y. Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell. : 55th SPSJ Symposium on Macromolecules. 2 版 巻 55. 2006. p. 5461-5462
Nishi, Kentaro ; Mori, Takeshi ; Niidome, Takuro ; Katayama, Yoshiki. / Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell. 55th SPSJ Symposium on Macromolecules. 巻 55 2. 版 2006. pp. 5461-5462
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