Evaluation of drug carrier responding to Matrix Metalloproteinase II in cancer cell

Kentaro Nishi, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

    研究成果: 会議への寄与タイプ学会誌査読

    抄録

    Matrix Metalloproteinase II (MMP II) plays a key role when cancer cells perform invasion and metastasis by degrading a collagen. Moreover, the expression of this proteinase is enhanced in bone destruction in rheumatoid arthritis. We succeeded in developing novel drug delivery system that can respond to MMP II. In our DDS, the micelle which is formed from amphiphilic copolymers is used as a drug carrier. The copolymer is composed of hydrophobic polymer main chain and hydrophilic peptide side chain which is linked to the main chain with substrate of MMP II. The micelle will be coagulated by digestion of the substrate by MMP II that is enhanced in cancer invasion and rheumatoid and will release the incorporated drug. To realize the DDS, we synthesized the copolymers and evaluated in vitro.

    本文言語英語
    ページ5461-5462
    ページ数2
    出版ステータス出版済み - 2006
    イベント55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本
    継続期間: 9月 20 20069月 22 2006

    その他

    その他55th Society of Polymer Science Japan Symposium on Macromolecules
    国/地域日本
    CityToyama
    Period9/20/069/22/06

    !!!All Science Journal Classification (ASJC) codes

    • 工学(全般)

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