Evaluation of echogenicity of the heart in Kawasaki disease

Hazumu Nagata, Kenichiro Yamamura, Kiyoshi Uike, Yasutaka Nakashima, Yuichiro Hirata, Eiji Morihana, Yumi Mizuno, Shiro Ishikawa, Toshiro Hara

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)


Pathologic studies of the heart in patients with Kawasaki disease (KD) revealed vasculitis, valvulitis, myocarditis, and pericarditis. However, there have been no studies on the quantitative determination of multi-site echogenicity of the heart in KD patients. It is also undetermined whether the degree of echogenicity of each site of the heart in patients with KD might be related to the response to intravenous immunoglobulin (IVIG) treatment. In 81 KD patients and 30 control subjects, we prospectively analyzed echogenicity of the heart. Echogenicity was measured in four sites: coronary artery wall (CAW), mitral valve (MV), papillary muscle (PM), and ascending aortic wall (AAo wall) by the calibrated integrated backscatters (cIBs). The cIB values of all measurement sites at acute phase in KD patients were significantly higher than those in control subjects (KD patients vs control subjects; CAW, 19.8±6.2 dB vs 14.5±2.0 dB, p<0.05; MV, 23.3±5.3 dB vs 16.0±3.3 dB, p<0.05; PM, 22.4±5.1 dB vs 12.7±1.9 dB, p<0.05; AAo wall, 25.3±5.6 dB vs 18.3±3.4 dB, p<0.05). The cIB values of CAW at the acute phase in IVIG nonresponders were significantly higher than those in responders. Conclusion: Echogenicity of the heart in KD patients at the acute phase increased not only in the coronary artery wall but also in other parts of the heart. Echogenicity of CAW might be helpful in determining the unresponsiveness of IVIG treatment.

ジャーナルEuropean Journal of Pediatrics
出版ステータス出版済み - 8 2014

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康


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