Evaluation of hydroxyapatite-putty as a hemostatic agent

Y. Momota, Y. Miyamoto, K. Ishikawa, M. Takechi, T. Yuasa, T. Toh, M. Nagayama, K. Suzuki

研究成果: Contribution to journalConference article査読


Although bone wax is often used as a hemostatic agent for bone in surgery, some problems in biocompatibility have been pointed out. Therefore, we have evaluated hydroxyapatite-putty (HAP-putty) as a hemostatic agent for bone. Adhesive strength of HAP-putty to bone increased with the amount of sodium alginate, reaching maximum value in case of containing 8% sodium alginate. An actual hemostatic ability of HAP-putty was evaluated using rabbits. Bleeding from bone was arrested within 3 minutes. Thus, HAP-putty showed excellent hemostatic ability. Soft tissue response to HAP-putty was evaluated in rabbit subcutaneous tissue. Histological observation revealed slight inflammatory response around HAP-putty. HAP-putty partially transformed to HAP 24 hours after the implantation. In conclusion, HAP-putty could be a useful hemostatic agent for bone due to its good hemostatic ability and excellent biocompatibility.

ジャーナルKey Engineering Materials
出版ステータス出版済み - 2001
イベント13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy
継続期間: 11 22 200011 26 2000

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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