Evaluation of liver parenchymal pressure and portal endothelium damage during radio frequency ablation in an in vivo porcine model

Kazuhiro Kotoh, Shusuke Morizono, Motoyuki Kohjima, Munechika Enjoji, Hironori Sakai, Makoto Nakamuta

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Background/aims: We previously developed a multi-step, incremental expansion method (multi-step method) for radio frequency ablation (RFA) in vitro, which prevented increases in pressure and reduced the ablation time as compared with other methods. In this study, we evaluated liver parenchymal pressure and portal endothelium damage during RFA with different devices and protocols in an in vivo porcine model. Method: Nine healthy female pigs were anaesthetized. RFA was performed with two different devices and protocols; one involved the use of a LeVeen needle with a single-step full expansion method or a multi-step method, and the other used a cool-tip needle with 40 or 60 W power. We measured the pressure in the liver parenchyma and the gallbladder during RFA. We also evaluated portal endothelium damage by NADH staining. Results: The multi-step method with the LeVeen electrode resulted in the lowest parenchymal and intra-gallbladder pressures (multi-step method < single-step method < cool-tip 40 W < cool-tip 60 W). In contrast, the ablation time was shortest with the cool-tip needle at 60 W (cool-tip 60 W <cool-tip 40 W = multi-step method <single-step method). NADH staining revealed severe endothelium damage after ablation with the cool-tip needle, but only slight damage with the LeVeen needle. Conclusion: Ablation with the LeVeen needle, especially when used with a multi-step protocol, produced less of an increase in liver parenchymal and intra-gallbladder pressures and less damage to portal endothelial cells than did the cool-tip electrode.

元の言語英語
ページ(範囲)1217-1223
ページ数7
ジャーナルLiver International
25
発行部数6
DOI
出版物ステータス出版済み - 12 1 2005

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Portal Pressure
Radio
Endothelium
Swine
Liver
Needles
Gallbladder
Pressure
NAD
Electrodes
Staining and Labeling
Equipment and Supplies
Endothelial Cells

All Science Journal Classification (ASJC) codes

  • Hepatology

これを引用

Evaluation of liver parenchymal pressure and portal endothelium damage during radio frequency ablation in an in vivo porcine model. / Kotoh, Kazuhiro; Morizono, Shusuke; Kohjima, Motoyuki; Enjoji, Munechika; Sakai, Hironori; Nakamuta, Makoto.

:: Liver International, 巻 25, 番号 6, 01.12.2005, p. 1217-1223.

研究成果: ジャーナルへの寄稿記事

Kotoh, Kazuhiro ; Morizono, Shusuke ; Kohjima, Motoyuki ; Enjoji, Munechika ; Sakai, Hironori ; Nakamuta, Makoto. / Evaluation of liver parenchymal pressure and portal endothelium damage during radio frequency ablation in an in vivo porcine model. :: Liver International. 2005 ; 巻 25, 番号 6. pp. 1217-1223.
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