Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma

H. Kurokawa, K. Miura, Yoshihisa Yamashita, S. Tokudome, T. Murata, M. Kajiyama

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

In the present study, we investigated the clinical and histopathological effects of CP therapy consisting of cisplatin (CDDP 50 mg/m2) or carboplatin (CBDCA 300 mg/m2) and peplomycin (PEP 5 mg/day) for 25 patients with oral squamous cell carcinoma. The effects of treatment and associated complications were as follows: 1) Complete response (CR) was achieved in 8 and partial response (PR) in 14 of the 25 cases. The overall clinical response rate was 88%. The histological response rate was 64%. 2) The clinical effects were not always consistent with the histopathological effects. There were discrepancies between the clinical and histopathological effects, especially in PR determined by clinical findings. 3) The principal adverse reaction was gastrointestinal disturbances, but symptoms were able to be controlled. Signs of hematologic toxicity and renal disturbance were mild and did not preclude the continuance of therapy. The results of this study indicated that neo-adjuvant chemotherapy with CDDP and PEP was highly effective for the local control of oral squamous cell carcinoma.

元の言語英語
ページ(範囲)1273-1278
ページ数6
ジャーナルJapanese Journal of Cancer and Chemotherapy
24
発行部数10
出版物ステータス出版済み - 9 24 1997

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Adjuvant Chemotherapy
Squamous Cell Carcinoma
Carboplatin
Peplomycin
Cisplatin
Therapeutics
Kidney
Peptamen

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Kurokawa, H., Miura, K., Yamashita, Y., Tokudome, S., Murata, T., & Kajiyama, M. (1997). Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. Japanese Journal of Cancer and Chemotherapy, 24(10), 1273-1278.

Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. / Kurokawa, H.; Miura, K.; Yamashita, Yoshihisa; Tokudome, S.; Murata, T.; Kajiyama, M.

:: Japanese Journal of Cancer and Chemotherapy, 巻 24, 番号 10, 24.09.1997, p. 1273-1278.

研究成果: ジャーナルへの寄稿記事

Kurokawa, H, Miura, K, Yamashita, Y, Tokudome, S, Murata, T & Kajiyama, M 1997, 'Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma', Japanese Journal of Cancer and Chemotherapy, 巻. 24, 番号 10, pp. 1273-1278.
Kurokawa H, Miura K, Yamashita Y, Tokudome S, Murata T, Kajiyama M. Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. Japanese Journal of Cancer and Chemotherapy. 1997 9 24;24(10):1273-1278.
Kurokawa, H. ; Miura, K. ; Yamashita, Yoshihisa ; Tokudome, S. ; Murata, T. ; Kajiyama, M. / Evaluation of neo-adjuvant chemotherapy for oral squamous cell carcinoma. :: Japanese Journal of Cancer and Chemotherapy. 1997 ; 巻 24, 番号 10. pp. 1273-1278.
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AU - Kajiyama, M.

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