Evaluation of series of isobenzofuranone dimers as PKCα ligands: Implication for the distance between the two ligand binding sites

Yoshiyasu Baba, Satoshi Mayumi, Go Hirai, Hidekazu Kawasaki, Yosuke Ogoshi, Takeshi Yanagisawa, Yuichi Hashimoto, Mikiko Sodeoka

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. To examine the distance between the two ligand binding sites (C1A and C1B) of PKC, we designed and synthesized two series of isobenzofuranone dimers. Peak binding activities were observed for the C3-acyl chain dimers having a C10-C12 linker and for the C7 dimers having a C14-C16.

本文言語英語
ページ(範囲)2969-2972
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
14
11
DOI
出版ステータス出版済み - 6 7 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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