Evaluation of series of isobenzofuranone dimers as PKCα ligands: Implication for the distance between the two ligand binding sites

Yoshiyasu Baba; Satoshi Mayumi; Go Hirai; Hidekazu Kawasaki; Yosuke Ogoshi; Takeshi Yanagisawa; Yuichi Hashimoto; Mikiko Sodeoka

doi:10.1016/j.bmcl.2004.02.098

Evaluation of series of isobenzofuranone dimers as PKCα ligands: Implication for the distance between the two ligand binding sites

Yoshiyasu Baba, Satoshi Mayumi, Go Hirai, Hidekazu Kawasaki, Yosuke Ogoshi, Takeshi Yanagisawa, Yuichi Hashimoto, Mikiko Sodeoka

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

6 被引用数 (Scopus)

抄録

Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. To examine the distance between the two ligand binding sites (C1A and C1B) of PKC, we designed and synthesized two series of isobenzofuranone dimers. Peak binding activities were observed for the C3-acyl chain dimers having a C₁₀-C₁₂ linker and for the C7 dimers having a C₁₄-C₁₆.

本文言語	英語
ページ（範囲）	2969-2972
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	14
号	11
DOI	https://doi.org/10.1016/j.bmcl.2004.02.098
出版ステータス	出版済み - 6月 7 2004
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/j.bmcl.2004.02.098

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引用スタイル

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title = "Evaluation of series of isobenzofuranone dimers as PKCα ligands: Implication for the distance between the two ligand binding sites",

abstract = "Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. To examine the distance between the two ligand binding sites (C1A and C1B) of PKC, we designed and synthesized two series of isobenzofuranone dimers. Peak binding activities were observed for the C3-acyl chain dimers having a C10-C12 linker and for the C7 dimers having a C14-C16.",

author = "Yoshiyasu Baba and Satoshi Mayumi and Go Hirai and Hidekazu Kawasaki and Yosuke Ogoshi and Takeshi Yanagisawa and Yuichi Hashimoto and Mikiko Sodeoka",

note = "Funding Information: This work was supported in part by grants from Uehara Memorial Foundation, and Hoh-ansha Foundation, Kanagawa Academy of Science and Technology Research Grants, a Grant-in-Aid for Creative Scientific Research (No 13NP0401) and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, and a Grant-in-Aid for the COE project, Giant Molecules and Complex Systems, from The Ministry of Education, Culture, Sports, Science, and Technology.",

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T2 - Implication for the distance between the two ligand binding sites

AU - Baba, Yoshiyasu

AU - Mayumi, Satoshi

AU - Hirai, Go

AU - Kawasaki, Hidekazu

AU - Ogoshi, Yosuke

AU - Yanagisawa, Takeshi

AU - Hashimoto, Yuichi

AU - Sodeoka, Mikiko

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