Evaluation of Teicoplanin Trough Values After the Recommended Loading Dose in Children With Associated Safety Analysis

Takaaki Yamada, Toshio Kubota, Mahoro Yonezawa, Hisanori Nishio, Shunsuke Kanno, Takahisa Yano, Daisuke Kobayashi, Nobuaki Egashira, Hidetoshi Takada, Toshiro Hara, Satohiro Masuda

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Background: This study evaluated whether the recommended teicoplanin loading dose (3 loading doses of 10 mg/kg every 12 hours) achieves a 15-30 μg/mL trough levels in 26 children (2-16 years). In addition, we examined the incidences of renal impairment and hepatic dysfunction in children treated with teicoplanin. Methods: This retrospective study was conducted between October 2008 and March 2014. Results: The percentage of patients with a trough level <10 and <15 μg/mL were 15.4% (4/26) and 46.2% (12/26), respectively. There were significant correlations between age and concentration/cumulative loading dose (C/D) ratio (P = 0.045), serum creatinine and C/D ratio (P < 0.001) and estimated glomerular filtration rate and C/D ratio (P = 0.005). Serum creatinine was significantly lower when trough levels were <15 μg/mL compared with ≥15 μg/mL. The incidences of renal impairment and hepatic dysfunction were 2.3% and 5.8%, respectively, with no significant difference between <20 and ≥20 μg/mL trough-level groups. Conclusions: The recommended loading dose may be insufficient to achieve 15-30 μg/mL in children with normal renal function. In addition, the target trough level ≥20 μg/mL for deep-seated infections seems to be safe in children.

元の言語英語
ページ(範囲)398-400
ページ数3
ジャーナルPediatric Infectious Disease Journal
36
発行部数4
DOI
出版物ステータス出版済み - 4 1 2017

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Teicoplanin
Safety
Kidney
Creatinine
Liver
Incidence
Serum
Glomerular Filtration Rate
Retrospective Studies
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

これを引用

Evaluation of Teicoplanin Trough Values After the Recommended Loading Dose in Children With Associated Safety Analysis. / Yamada, Takaaki; Kubota, Toshio; Yonezawa, Mahoro; Nishio, Hisanori; Kanno, Shunsuke; Yano, Takahisa; Kobayashi, Daisuke; Egashira, Nobuaki; Takada, Hidetoshi; Hara, Toshiro; Masuda, Satohiro.

:: Pediatric Infectious Disease Journal, 巻 36, 番号 4, 01.04.2017, p. 398-400.

研究成果: ジャーナルへの寄稿記事

Yamada, Takaaki ; Kubota, Toshio ; Yonezawa, Mahoro ; Nishio, Hisanori ; Kanno, Shunsuke ; Yano, Takahisa ; Kobayashi, Daisuke ; Egashira, Nobuaki ; Takada, Hidetoshi ; Hara, Toshiro ; Masuda, Satohiro. / Evaluation of Teicoplanin Trough Values After the Recommended Loading Dose in Children With Associated Safety Analysis. :: Pediatric Infectious Disease Journal. 2017 ; 巻 36, 番号 4. pp. 398-400.
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abstract = "Background: This study evaluated whether the recommended teicoplanin loading dose (3 loading doses of 10 mg/kg every 12 hours) achieves a 15-30 μg/mL trough levels in 26 children (2-16 years). In addition, we examined the incidences of renal impairment and hepatic dysfunction in children treated with teicoplanin. Methods: This retrospective study was conducted between October 2008 and March 2014. Results: The percentage of patients with a trough level <10 and <15 μg/mL were 15.4{\%} (4/26) and 46.2{\%} (12/26), respectively. There were significant correlations between age and concentration/cumulative loading dose (C/D) ratio (P = 0.045), serum creatinine and C/D ratio (P < 0.001) and estimated glomerular filtration rate and C/D ratio (P = 0.005). Serum creatinine was significantly lower when trough levels were <15 μg/mL compared with ≥15 μg/mL. The incidences of renal impairment and hepatic dysfunction were 2.3{\%} and 5.8{\%}, respectively, with no significant difference between <20 and ≥20 μg/mL trough-level groups. Conclusions: The recommended loading dose may be insufficient to achieve 15-30 μg/mL in children with normal renal function. In addition, the target trough level ≥20 μg/mL for deep-seated infections seems to be safe in children.",
author = "Takaaki Yamada and Toshio Kubota and Mahoro Yonezawa and Hisanori Nishio and Shunsuke Kanno and Takahisa Yano and Daisuke Kobayashi and Nobuaki Egashira and Hidetoshi Takada and Toshiro Hara and Satohiro Masuda",
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AU - Kubota, Toshio

AU - Yonezawa, Mahoro

AU - Nishio, Hisanori

AU - Kanno, Shunsuke

AU - Yano, Takahisa

AU - Kobayashi, Daisuke

AU - Egashira, Nobuaki

AU - Takada, Hidetoshi

AU - Hara, Toshiro

AU - Masuda, Satohiro

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