Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin

Seicho Makihira, Hiroki Nikawa, Takahiro Shuto, Masahiro Nishimura, Yuichi Mine, Koichiro Tsuji, Keishi Okamoto, Yuhiro Sakai, Masanori Sakai, Naoya Imari, Satoshi Iwata, Mika Takeda, Fumio Suehiro

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

JH8194 induces osteoblast differentiation, although it was originally designed to improve antifungal activity. This suggests that JH8194 is useful for implant treatment. Therefore, the aim of this study was to evaluate the osseointegration capacity of JH8194-modified titanium dental implant fixtures (JH8194-Fi). The implants were randomly implanted into the edentulous ridge of dog mandibles. Healing abutments were inserted immediately after implant placement. Three weeks later, peri-implant bone levels, the first bone-to-implant contact points, and trabecular bone formation surrounding the implants were assessed by histological and digital image analyses based on microcomputed tomography (microCT). The histological analysis revealed an enhancement of mature trabecular bone around the JH8194-Fi compared with untreated fixtures (control-Fi). Similarly, microCT combined with analysis by Zed View also showed increased trabecular bone formation surrounding the JH8194-Fi compared with the control-Fi (Student's t-test, P < 0.05). JH8194 may offer an alternative biological modification of titanium surfaces to enhance trabecular bone formation around dental implants, which may contribute to the transient acquirement of osseointegration and the long-term success of implant therapy.

本文言語英語
ページ(範囲)2765-2772
ページ数8
ジャーナルJournal of Materials Science: Materials in Medicine
22
12
DOI
出版ステータス出版済み - 12 2011

All Science Journal Classification (ASJC) codes

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学

フィンガープリント

「Evaluation of trabecular bone formation in a canine model surrounding a dental implant fixture immobilized with an antimicrobial peptide derived from histatin」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル