Evidence against the central nervous system involved in altered reflex control of sympathetic nerve activity by atrial natriuretic peptide

S. Suzuki, A. Takeshita, T. Imaizumi, Y. Hirooka, M. Yoshida, M. Nakamura

    研究成果: Contribution to journalArticle査読

    1 被引用数 (Scopus)

    抄録

    This study aimed to examine whether atrial natriuretic peptide (ANP) alters arterial baroreceptor control of sympathetic nerve activity (SNA) by acting on the central nervous system (CNS). In rabbits anesthetized with αchloralose, we examined changes in arterial pressure and renal SNA in response to graded electrical stimulation (1.7, 3.3, 5.0 Hz) of aortic depressor nerves during the intravenous (IV) infusion of saline or αhuman atrial natriuretic peptide (αhANP) (0.1, 1.0 μg/kg/min) or after the intracerebroventricular (ICV) injections of saline or αhANP (3, 10 μg). Sinoaortic denervation and bilateral vagotomy were done before examination in all rabbits to eliminate the influence of the known effects of ANP on arterial and cardiac receptors. IV αhANP decreased arterial pressure but did not alter renal SNA. ICV αhANP did not change arterial pressure or renal SNA. Arterial pressure and renal nerve responses to graded electrical stimulation of aortic depressor nerves were not altered by IV or ICV αhANP. These results suggest that αhANP does not modulate control of renal SNA by acting on CNS.

    本文言語英語
    ページ(範囲)263-268
    ページ数6
    ジャーナルClinical and Experimental Hypertension
    A10
    S1
    DOI
    出版ステータス出版済み - 1988

    All Science Journal Classification (ASJC) codes

    • 内科学
    • 生理学

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