Evidence of lipid rafts based on the partition and dynamic behavior of sphingomyelins

Masanao Kinoshita, Kenichi G.N. Suzuki, Michio Murata, Nobuaki Matsumori

研究成果: Contribution to journalReview article査読

13 被引用数 (Scopus)

抄録

Sphingomyelin (SM)-rich membrane nano-domains, called lipid rafts, have attracted the interest of researchers due to their potential involvement in the formation of signaling platform. Although there are many studies on lipid rafts, the direct observation of lipid rafts is still challenging owing to two critical reasons. One is the lack of an appropriate fluorescent probe mimicking the native behavior of raft lipids; fluorescent labeling often alters the intrinsic disposition of raft lipids. The other is their spatio-temporal stability; the size of lipid rafts is much smaller than the optical resolution of usual microscopy and their lifetime is much shorter than image acquisition duration. These issues are hampering the visualization of lipid rafts. Our review highlights the recent advances in microscopic techniques to visualize the partition and dynamic behavior of SMs, disclosing the detailed structure of lipid rafts. Moreover, we will elucidate the importance of SM-SM interactions in the stabilization of signaling platforms as lipid rafts.

本文言語英語
ページ(範囲)84-95
ページ数12
ジャーナルChemistry and Physics of Lipids
215
DOI
出版ステータス出版済み - 9 2018

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 有機化学
  • 細胞生物学

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