Evolutionary dynamics of escape from biomedical intervention

Yoh Iwasa, Franziska Michor, Martin A. Nowak

研究成果: Contribution to journalArticle査読

71 被引用数 (Scopus)

抄録

Viruses, bacteria, eukaryotic parasites, cancer cells, agricultural pests and other inconvenient animates have an unfortunate tendency to escape from selection pressures that are meant to control them. Chemotherapy, anti-viral drugs or antibiotics fail because their targets do not hold still, but evolve resistance. A major problem in developing vaccines is that microbes evolve and escape from immune responses. The fundamental question is the following: if a genetically diverse population of replicating organisms is challenged with a selection pressure that has the potential to eradicate it, what is the probability that this population will produce escape mutants? Here, we use multi-type branching processes to describe the accumulation of mutants in independent lineages. We calculate escape dynamics for arbitrary mutation networks and fitness landscapes. Our theory shows how to estimate the probability of success or failure of biomedical intervention, such as drug treatment and vaccination, against rapidly evolving organisms.

本文言語英語
ページ(範囲)2573-2578
ページ数6
ジャーナルProceedings of the Royal Society B: Biological Sciences
270
1533
DOI
出版ステータス出版済み - 12 22 2003

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)
  • 環境科学(全般)
  • 農業および生物科学(全般)

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