Ex Vivo Transfer of Nuclear Factor-κB Decoy Ameliorates Hepatic Cold Ischemia/Reperfusion Injury

T. Yoshizumi, Y. Ikeda, Y. Kaneda, K. Sueishi

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. Specific inhibition of these cytokines may improve viability of the hepatic graft upon reperfusion. Herein we have assessed the efficacy of cis element decoy against nuclear factor-κB binding site delivery to the hepatic tissue in a rodent liver transplantation model. At 8 hours after reperfusion of the liver, significant reduction was noted in the livers treated with decoy in the release of cytosolic enzymes from the hepatocytes and in serum tumor necrosis factor α (P < .05). The neutrophilic infiltration into the hepatic grafts was significantly suppressed in the livers treated with decoy oligodeoxynucleotides (ODNs). Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model.

元の言語英語
ページ(範囲)1504-1507
ページ数4
ジャーナルTransplantation Proceedings
41
発行部数5
DOI
出版物ステータス出版済み - 6 1 2009

Fingerprint

Cold Ischemia
Transfer Factor
Reperfusion Injury
Liver
Transplants
Oligodeoxyribonucleotides
Liver Transplantation
Reperfusion
Rodentia
Binding Sites
Cytokines
Hepatocytes
Tumor Necrosis Factor-alpha
Enzymes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

これを引用

Ex Vivo Transfer of Nuclear Factor-κB Decoy Ameliorates Hepatic Cold Ischemia/Reperfusion Injury. / Yoshizumi, T.; Ikeda, Y.; Kaneda, Y.; Sueishi, K.

:: Transplantation Proceedings, 巻 41, 番号 5, 01.06.2009, p. 1504-1507.

研究成果: ジャーナルへの寄稿記事

@article{8a65c15827684b8883e24cd294988439,
title = "Ex Vivo Transfer of Nuclear Factor-κB Decoy Ameliorates Hepatic Cold Ischemia/Reperfusion Injury",
abstract = "Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. Specific inhibition of these cytokines may improve viability of the hepatic graft upon reperfusion. Herein we have assessed the efficacy of cis element decoy against nuclear factor-κB binding site delivery to the hepatic tissue in a rodent liver transplantation model. At 8 hours after reperfusion of the liver, significant reduction was noted in the livers treated with decoy in the release of cytosolic enzymes from the hepatocytes and in serum tumor necrosis factor α (P < .05). The neutrophilic infiltration into the hepatic grafts was significantly suppressed in the livers treated with decoy oligodeoxynucleotides (ODNs). Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model.",
author = "T. Yoshizumi and Y. Ikeda and Y. Kaneda and K. Sueishi",
year = "2009",
month = "6",
day = "1",
doi = "10.1016/j.transproceed.2008.10.101",
language = "English",
volume = "41",
pages = "1504--1507",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Ex Vivo Transfer of Nuclear Factor-κB Decoy Ameliorates Hepatic Cold Ischemia/Reperfusion Injury

AU - Yoshizumi, T.

AU - Ikeda, Y.

AU - Kaneda, Y.

AU - Sueishi, K.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. Specific inhibition of these cytokines may improve viability of the hepatic graft upon reperfusion. Herein we have assessed the efficacy of cis element decoy against nuclear factor-κB binding site delivery to the hepatic tissue in a rodent liver transplantation model. At 8 hours after reperfusion of the liver, significant reduction was noted in the livers treated with decoy in the release of cytosolic enzymes from the hepatocytes and in serum tumor necrosis factor α (P < .05). The neutrophilic infiltration into the hepatic grafts was significantly suppressed in the livers treated with decoy oligodeoxynucleotides (ODNs). Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model.

AB - Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. Specific inhibition of these cytokines may improve viability of the hepatic graft upon reperfusion. Herein we have assessed the efficacy of cis element decoy against nuclear factor-κB binding site delivery to the hepatic tissue in a rodent liver transplantation model. At 8 hours after reperfusion of the liver, significant reduction was noted in the livers treated with decoy in the release of cytosolic enzymes from the hepatocytes and in serum tumor necrosis factor α (P < .05). The neutrophilic infiltration into the hepatic grafts was significantly suppressed in the livers treated with decoy oligodeoxynucleotides (ODNs). Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model.

UR - http://www.scopus.com/inward/record.url?scp=67249093360&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67249093360&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2008.10.101

DO - 10.1016/j.transproceed.2008.10.101

M3 - Article

C2 - 19545666

AN - SCOPUS:67249093360

VL - 41

SP - 1504

EP - 1507

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 5

ER -