Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice

Honglian Tong, Yoshiyuki Miyazaki, Masanori Yamazaki, Hiromitsu Hara, Herman Waldmann, Shohei Hori, Hiroki Yoshida

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

抄録

Epstein-Barr virus-induced gene-3 (EBI-3) associates with p28 to form interleukin-27 (IL-27) or with IL-12p35 to form IL-35. Both IL-27 and IL-35 have immunosuppressive functions and especially IL-35 has been implicated in the suppressive function of regulatory T cells (Treg). To address the role of EBI-3 in immune regulation, delayed-type hypersensitivity (DTH) responses were examined in EBI-3-deficient (EBI-3-/-) mice. EBI-3-/- mice developed deteriorated DTH responses as shown by the enhanced footpad swelling and augmented infiltration of inflammatory cells into the antigen-challenged footpads as compared with wild-type (WT) mice. While EBI-3-deficiency showed little effects on antigen-specific IFN-γ production of lymph node cells, IL-17 production was drastically augmented in EBI-3-/- cells as compared with in WT cells. In addition, reduced IL-10 production was also evident in EBI-3-/- CD4+ T cells. Interestingly, the development and suppressive function of Treg to inhibit effector T cell proliferation was not affected by EBI-3-deficiency. These data clearly demonstrated the immunosuppressive function of EBI-3 and provided complementary evidence that EBI-3 and EBI-3-containing cytokines might be taken into consideration as potential targets for some immune-related diseases.

元の言語英語
ページ(範囲)108-115
ページ数8
ジャーナルImmunology Letters
128
発行部数2
DOI
出版物ステータス出版済み - 2 1 2010

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Delayed Hypersensitivity
Human Herpesvirus 4
Genes
Interleukin-27
Immunosuppressive Agents
Interleukin-12 Subunit p35
T-Lymphocytes
Antigens
Interleukin-17
Immune System Diseases
Regulatory T-Lymphocytes
Interleukin-10
Lymph Nodes
Cell Proliferation
Cytokines

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

これを引用

Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice. / Tong, Honglian; Miyazaki, Yoshiyuki; Yamazaki, Masanori; Hara, Hiromitsu; Waldmann, Herman; Hori, Shohei; Yoshida, Hiroki.

:: Immunology Letters, 巻 128, 番号 2, 01.02.2010, p. 108-115.

研究成果: ジャーナルへの寄稿記事

Tong, Honglian ; Miyazaki, Yoshiyuki ; Yamazaki, Masanori ; Hara, Hiromitsu ; Waldmann, Herman ; Hori, Shohei ; Yoshida, Hiroki. / Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice. :: Immunology Letters. 2010 ; 巻 128, 番号 2. pp. 108-115.
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